TRANSGENIC SKIN-TESTING SYSTEMS

摘要

The present invention relates to transgenic non-human animals which can be used as model skin-testing systems. Recombinant DNA techniques are used to produce novel genetic constructs which confer upon their transgenic hosts the ability to responds, in a quantifiable way, to physical or chemical stimuli applied to their skin. The transgenic skin-testing system offers a means for identifying effective skin-protective (i.e. ultraviolet light blocking) agents and also provides methods for evaluating the effects of ultraviolet radiation, chemical and cosmetic compounds on the skin, skin pathology, and aging.