A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.
申请公布号
US4980283(A)
申请公布日期
1990.12.25
申请号
US19890360626
申请日期
1989.06.02
申请人
MERCK & CO., INC.
发明人
HUANG, LEEYUAN;DUNN, JR., JOSEPH;KOUPAL, LAWRENCE;LIESCH, JERROLD;HENSENS, OTTO;WOODRUFF, H. BOYD