摘要 |
A device is disclosed which achieves a constant rate of release of an active ingredient in the temperature range of 5 DEG to 45 DEG C., which comprises a container having at least a portion of its surface membrane consisting essentially of polyethylene, polypropylene, or copolymers thereof, said membrane having a thickness of less than 6 mil, and within the container a solution of active ingredient in a solvent in contact with a negative release modulator, wherein the negative release modulator is less miscible with the solution at 5 DEG C. than at 45 DEG C.
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