发明名称 |
3',4'-DIDEOXY-3'-FLUOROKANAMYCIN B AND PRODUCTION THEREOF |
摘要 |
<p>New Compound, 3 min ,4 min -dideoxy-3 min -fluorokanamycin B is now provided, which is useful as antibacterial agent. …<??>3 min ,4 min -Dideoxy-3 min -fluorokanamycin B is prepared by a process comprising halogenating an N,O-protected derivative of 3 min -deoxy-3 min -fluoro-4 min -O-sulfonylkanamycin B with a metal halide, reducing the resulting 4 min -halogenated 3 min -deoxy-3 min -fluorokanamycin B derivative to convert its 4 min -halo group into a hydrogen atom, and thereby to produce an N,O-protected derivative of 3 min ,4 min -dideoxy-3 min -fluorokanamycin B and removing the remaining amino-protecting groups and the remaining hydroxyl-protecting groups from the reduction product by conventional deprotecting methods.</p> |
申请公布号 |
EP0214904(B1) |
申请公布日期 |
1990.12.19 |
申请号 |
EP19860401892 |
申请日期 |
1986.08.28 |
申请人 |
ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI |
发明人 |
UMEZAWA, HAMAO;UMEZAWA, SUMIO;TSUCHIYA, TSUTOMU;KOBAYASHI, YOSHIHIKO |
分类号 |
C07H15/234;A61K31/70;A61K31/7028;A61K31/7034;A61K31/7036;A61P31/04;C07H15/236 |
主分类号 |
C07H15/234 |
代理机构 |
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