| 摘要 |
(A) 2-Arylbenzo(b)-thiophene 3(2H)-one-1.1-dioxide derivs. (I) - R = CF3, CH3 or NO2. - (B) 2-Arylnaphtho(2,3-b)-thiophene 3(2H)-one-1,1-dioxides (II): - R1 = phenyl, tolyl, phenyl substd. by methoxy, halogen, nitro, trifluoromethyl, trifluoromethylthio, trifluoromethylsulphinyl or trifluoromethylsulphonyl; alpha- and beta-naphthyl - Keto- and enol structures of both compounds are included. - (C) Intermediate compounds (III): - R = methyl, trifluoromethyl, nitro or the residue of a condensed ring at pos. 4 and 5; - Y = -S, -SO2 or -SO - R1 = phenyl, tolyl, phenyl substd. by methoxy, nitro, halogen, trifluoromethyl, trifluoromethylthio, trifluoromethylsulphinyl or trifluoromethylsulphonyl; alpha- or beta-naphthyl; R2 = or -O - R5; R3 and R4 are H, alkyl (C1-C6), hydroxyalkyl (max C6), alkoxyalkyl (max C6), or carbalkoxyalkyl (max C6); or: R3, R4 and N may together form a heterocyclic ring. - R5 = H, alkyl(max C6), alkoxyalkyl (max C6), carbalkoxyalkyl (max C6), benzyl or substd. benzyl. - Pharmaceutically acceptable metal salts and acid addition salts are included. - (I) and (II) have anti-inflammatory activity in mammals and inhibit the formation of granuloma in connective tissue. - (III) have hypocholesteraemic activity.
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