| 摘要 |
Hexahydro- and octahydronaphthyl-ethyl-tetrahydropyranone cpds. of formula (I) and lactone ring opened derivs. of formula (II) and pharmaceutically acceptable salts are new: where R1= 1-10C alkyl(opt. substd. by halogen,OH, 1-10C alkoxy, 1-5C alkoxycarbonyl, 1-5C acyloxy, 3-8C cycloalkyl, phenyl (opt. substd. by X and Y), 1-10C alkyl-S(O)n- (where n=0,1 or 2), 3-8C cycloalkyl -S(O)n-, phenyl-S(O)n-(opt. substd. by X and Y), and/or oxo gp(s), 1-10C alkoxy, 2-10C alkenyl, 3-8C cycloalkyl (opt. substd. by an opt. substd 1-10C alkyl(as above), 1-10C alkyl-S(O)n-, 3-8C cycloalkyl-S(O)n-, phenyl-S(O)n- (opt. substd. by X and Y), halogen, OH, 1-10C alkoxy, 1-5C alkoxycarbonyl, 1-5C acyloxy or phenyl(opt. substd. by X and Y)), phenyl (opt. substd. byX and Y), NH2, mono or di(1-5C alkyl)amino, phenylamino (opt. substd. by X and Y, phenyl 1-10C alkylamino (opt. substd. by X and Y), piperidinyl, pyrrolidinyl, piperazinyl, morpholinyl, thiomorpholinyl or -SR3; R2=H, Me or AfxOH; R3 = 1-10C alkyl or phenyl opt. substd. by X and Y; X,Y= OH, halogen, CF3, 1-3C alkoxy, 1-3C alkyl carbonyloxy, phenylcarbonyloxy, 1-3C alkoyxcarbonyl, phenoxycarbonyl, H or 1-5C alkyl; Z=H, 1-5C alkyl(opt. substd. by a phenyl, NMe2 or NHAc gp.) or 2,3-dibydroxypropyl; halogen = Cl or F; and bond a is a single or double bond. |
