发明名称 |
REAGENTS FOR RAPID PEPTIDE SYNTHESIS |
摘要 |
This invention relates to compounds of the formula: <CHEM> wherein R is an electron withdrawing group; R1 is H or COZ; X1 and X2 are independently H, lower alkyl, aryl, aryl lower-alkyl or polystyrene or R and X1 taken together with the carbon atoms to which they are attached form a ring containing from 4 to 15 ring carbon atoms and may contain up to 2 heteroatoms, wherein the heteroatoms are O, S, or N; and Z is an amino acid residue, a peptide residue or a leaving group. The compounds of the present invention are adaptable as blocking or protecting groups for an amine composition useful in peptide synthesis. The present invention is also directed to a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group. |
申请公布号 |
AU5689790(A) |
申请公布日期 |
1990.12.13 |
申请号 |
AU19900056897 |
申请日期 |
1990.06.08 |
申请人 |
RESEARCH CORPORATION TECHNOLOGIES, INC. |
发明人 |
LOUIS A. CARPINO;MICHAEL PHILBIN |
分类号 |
C07D333/16;C07C69/96;C07C271/28;C07C317/08;C07C317/14;C07C317/18;C07C317/48;C07C321/18;C07C321/28;C07C323/14;C07D333/64;C07F7/08;C07K1/04;C07K1/06;C07K1/113;C07K5/06;C07K5/08;C07K14/575;C07K14/655 |
主分类号 |
C07D333/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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