发明名称 Phenethanolamine derivatives, processes for their preparation and pharmaceutical compositions containing them.
摘要 <p>The invention relates to compounds of the general formula (I) &lt;CHEM&gt; and physiologically acceptable salts and solvates thereof; wherein: R&lt;1&gt; and R&lt;2&gt; each independently represent a hydrogen atom or a C1-3alkyl group with the proviso that the sum total of carbon atoms in R&lt;1&gt; and R&lt;2&gt; is not more than 4; X represents a direct bond or a C1-7alkylene, C2-7alkenylene or C2-7alkynylene group and Y represents a direct bond or a C1-6alkylene, C2-6alkenylene or C2-6alkynylene group with the proviso that the sum total of carbon atoms in X and Y is not more than 10; W represents a group &lt;CHEM&gt; wherein Z represents a group R&lt;3&gt;(CH2)q where q is 0, 1 or 2 and R&lt;3&gt; is a group R&lt;4&gt;CONH-, R&lt;4&gt;NHCONH-, R&lt;4&gt;R&lt;5&gt;NSO2NH-, R&lt;6&gt;SO2NH- or -OH; R&lt;4&gt; and R&lt;5&gt; each represent a hydrogen atom or a C1-3alkyl group; R6 represents a C1-3alkyl group; R&lt;7&gt; represents a chlorine atom or the group -CF3; A represents a straight or branched C1-6alkyl group, a C3-8cycloalkyl group, either of which may be saturated or unsaturated, or a C1-6alkoxy group, with the proviso that the sum total of carbon atoms in A and Y is not less than 5. The invention also relates to processes for making the compounds of formula (I) and to pharmaceutical compositions containing them as active ingredient. The compounds of formula (I) have a stimulant action at beta 2-adrenoreceptors and are useful in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.</p>
申请公布号 EP0401966(A1) 申请公布日期 1990.12.12
申请号 EP19900304327 申请日期 1990.04.23
申请人 GLAXO GROUP LIMITED 发明人 SKIDMORE, IAN FREDERICK,C/O GLAXO GROUP RES.LTD.;LUNTS,LAWRENCE HENRY CHARLES,C/O GLAXO GROUP LTD.;FINCH, HARRY C/O GLAXO GROUP RESEARCH LTD.;NAYLOR, ALAN C/O GLAXO GROUP RESEARCH LIMITED;CAMPBELL, IAN BAXTER C/O GLAXO GROUP RES.LTD.;WILLBE, CHARLES C/O GLAXO GROUP RESEARCH LTD.;MITCHELL, WILLIAM LEONARD C/O GLAXO GROUP RES.LTD.;SWANSON, STEPHEN C/O GLAXO GROUP RESEARCH LIMITED;JUDKINS, BRIAN DAVID C/O GLAXO GROUP RES.LTD.
分类号 C07C217/46;C07C307/06;A61K31/135;A61K31/18;C07C213/00;C07C217/08;C07C233/36;C07C233/43;C07C311/08;C07C275/10;C07C275/14;C07C311/04;C07C311/35 主分类号 C07C217/46
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