| 摘要 |
HOE 89/S 008 7H-Benzo¢b!pyrazino¢1,2-d!pyrrolo¢3,2,1-jk!¢1,4!-benzodiazepines, a process for their preparation and their use as medicaments The present invention relates to 7H-benzo¢b!pyrazino-¢1,2-d!pyrrolo¢3,2,1-jk!¢1,4!benzodiazepines of the formula wherein R is hydrogen, loweralkyl, or a group of the formula COO(CR1Z)mCR2R3R4, wherein R1, R2, R3 and R4 are independently hydrogen or loweralkyl, Z is hydrogen, loweralkyl, or halogen, and m is 0 or 1; X and Y are independently hydrogen, halogen, loweralkyl, or trifluoromethyl; the dotted line represents an optional carbon-tocarbon bond; an optical isomer thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for treating depression alone or in combination with inert adjuvants. The invention relates also to a process and intermediates for the preparation of the above compounds.
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