Acylated derivatives of etoposide.

摘要

The epipodophyllotoxin glucosides disclosed are acylated at herein one or both sugar hydroxyl groups. These compounds exhibit significant activity against P388 murine leukemia <CHEM> wherein R<2> is H and R<1> is selected from the group consisting of (C1-10)alkyl, (C2-10)alkenyl, (C5-6)cycloalkyl, 2-furyl, 2-thienyl, (C6-10)aryl, and (C7-14)aralkyl; or R<1> and R<2> are each (C1-10)alkyl; or R<1>, R<2> and the carbon to which they are attached together represent (C5-6)cycloalkyl; one of R<3> and R<4> is H and the other is selected from the group consisting of (C1-5)alkanoyl and benzoyl; or R<3> and R<4> are the same or different and are selected from the group consisting of (C1-5)alkanoyl and benzoyl; R<5> is H or a phosphate group.