发明名称 |
COMPOUNDS HAVING ONE OR MORE AMINOSULFONYLOXY RADICALS USEFUL AS PHARMACEUTICALS |
摘要 |
AHR-484 Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p-A-¢-OS(0)2NR1R2!z wherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of -OS(0)2NR1R2 groups and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.
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申请公布号 |
CA2018700(A1) |
申请公布日期 |
1990.12.12 |
申请号 |
CA19902018700 |
申请日期 |
1990.06.11 |
申请人 |
ROBINS (A.H.) COMPANY, INCORPORATED |
发明人 |
LO, YOUNG S.;WELSTEAD, WILLIAM J., JR.,;NOLAN, JOSEPH C.;WALSH, DAVID A. |
分类号 |
A61K31/255;A61K31/33;A61K31/335;A61K31/357;A61K31/40;A61K31/4015;A61K31/403;A61K31/404;A61K31/41;A61K31/415;A61K31/425;A61K31/426;A61K31/433;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4418;A61K31/443;A61K31/445;A61K31/451;A61K31/47;A61P3/02;A61P19/10;A61P29/00;A61P43/00;C07C307/02;C07D207/26;C07D207/27;C07D209/08;C07D211/22;C07D211/96;C07D213/65;C07D215/26;C07D215/32;C07D233/54;C07D233/60;C07D249/08;C07D277/14;C07D277/24;C07D277/28;C07D285/10;C07D311/16;C07D317/22;C07D319/20;C07D405/12;C07D493/04;C07D521/00;C07H11/00;(IPC1-7):C07C307/02;A61K31/395;C07D233/61;A61K31/70 |
主分类号 |
A61K31/255 |
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