METHOD FOR PRODUCING SUSTAINED RELEASE FORMULATION

摘要

: The present invention is directed to a method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps of: (i) preparing a uniform and highly concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture of water and a hydrophilic organic solvent under one of the conditions selected from: (A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration; (B) chemically modified collagen and/or gelatin is employed; and (C) glucose is added to the mixture; (ii) molding the resultant mixture; and (iii) gradually eliminating the solvent from the molded product.