| 摘要 |
Novel antihypertensive and coronary dilating asymmetsic diesters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): (I) wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R1 is hydrogen, hydroxy or an alkyl radical having from 1 to b carbon atoms, and R2 is hydrogen or methyl. The subject diesters may be prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids. |
