发明名称 |
Aminocyclopentanol acids and esters and their preparation and pharmaceutical formulation |
摘要 |
Compounds are described of the formula <IMAGE> in which R1 is H, C1-6 alkyl or C7-10 aralkyl; W is C1-7 alkylene; X is cis or trans -CH=CH- or -CH2CH2-; n is 1 or 2; Y is a saturated heterocyclic amino group having 5-8 ring members; R2 is (i) substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or (ii) substituted or unsubstituted cinnamyl; and their salts and solvates. These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and antiasthmatic agents.
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申请公布号 |
US4977163(A) |
申请公布日期 |
1990.12.11 |
申请号 |
US19880183293 |
申请日期 |
1988.04.11 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
COLLINGTON, ERIC W.;HALLETT, PETER;WALLIS, CHRISTOPHER J.;WADSWORTH, ALAN;HAYES, NORMAN F. |
分类号 |
C07C405/00;C07D295/112;C07D295/116;C07D295/155;C07D307/00;C07D309/12;C07D333/16 |
主分类号 |
C07C405/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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