发明名称 |
2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives, and their application in treating depressive state, anxiety state or hypertension |
摘要 |
A compound which is a pyrido[3,4-b]derivative of formula (I) <IMAGE> (I) in which R is a hydrogen atom or an alkyl carbonyl, arylalkylcarbonyl or arylcarbonyl group of formula COR1 wherein R1 is a C1-C6 alkyl group, a benzyl group or a phenyl group unsubstituted or substituted with 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, C1-C3 alkyl and C1-C3 alkoxy groups or R is an alkoxycarbonyl or benzyloxycarbonyl group of formula COOR2 wherein R2 is a C1-C6 alkyl group or a benzyl group, or R is a substituted aminocarbonyl group of formula CONHR3 wherein R3 is a C1-C6 alkyl group or a phenyl group, or R is an arylsulphonyl group of formula SO2R4 wherein R4 is a phenyl group, or a pharmacologically acceptable acid addition salt thereof useful for treating hypertension, depressive state or anxiety state.
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申请公布号 |
US4977159(A) |
申请公布日期 |
1990.12.11 |
申请号 |
US19880228751 |
申请日期 |
1988.08.05 |
申请人 |
SYNTHELABO |
发明人 |
SEVRIN, MIREILLE;GEORGE, PASCAL;MENIN, JACQUES;MOREL, CLAUDE;BIGG, DENNIS |
分类号 |
A61K31/445;A61P9/00;A61P25/20;A61P25/24;A61P25/26;A61P43/00;C07D471/04 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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