发明名称 |
PRIMARY BILIARY CIRRHOSIS AUTOANTIGEN |
摘要 |
PCT No. PCT/AU87/00427 Sec. 371 Date Sep. 22, 1988 Sec. 102(e) Date Sep. 22, 1988 PCT Filed Dec. 16, 1987 PCT Pub. No. WO88/04689 PCT Pub. Date Jun. 30, 1988.A DNA molecule is provided which comprises a nucleotide sequence substantially corresponding to all or a portion of the base sequence coding for the mitochondrial autoantigen of primary biliary cirrhosis. This DNA molecule may be linked to an expression control sequence. A synthetic peptide or polypeptide is provided which includes at least an amino acid sequence substantially as shown in FIG. 6 or FIG. 8. This synthetic peptide or polypeptide may be prepared by expression of a host cell which has been transformed with a recombinant DNA molecule as described above, or by chemical synthesis. |
申请公布号 |
AU604087(B2) |
申请公布日期 |
1990.12.06 |
申请号 |
AU19880010868 |
申请日期 |
1987.12.16 |
申请人 |
AMRAD CORPORATION LIMITED |
发明人 |
ROSS LEON COPPEL;MERRILL ERIC GERSHWIN |
分类号 |
G01N33/53;A61K38/00;A61P37/04;C07G99/00;C07H21/04;C07K7/08;C07K14/00;C07K14/47;C12N1/20;C12N1/21;C12N9/10;C12N15/00;C12N15/09;C12P21/00;C12P21/02;C12R1/19;G01N33/543;G01N33/564 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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