Geminally substituted thiaheterocyclic carboxylic acids and derivatives thereof.

摘要

Novel thromboxane receptor antagonists are disclosed, having the formula <CHEM> wherein: A is aryl, optionally substituted with halogen, lower alkoxy, carboalkoxy, lower alkyl, alkylamino, or phenyl; X is -CH2 or -NH; R1 is COOH, COO-alkali metal (such as Na, K, or Li), COO-lower alkyl, CONHSO2R2, or 5-tetrazolyl; R2 is lower alkyl or aryl; m is 0, 1, or 2; and p is 2, 3, 4 or 5. Also disclosed are novel intermediates of formula I compounds.