发明名称 |
DIVALENT METAL SALTS OF INDOMETHACIN |
摘要 |
The present invention provides a method for the treatment of infllammation and pain in a mammal requiring such treatment, comprising administering to said mammal an anti-inflammatory and analgesically effective amount of an indomethacin salt of a divalent metal capable of forming a stable complex with indomethacin, or of a pharmaceutical composition comprising said indomethacin salt together with a pharmaceutically acceptable carrier, diluent and/or excipient. The present invention also provides a process for the preparation of an indomethacin salt of a divalent metal capable of forming a stable complex with indomethacin comprising forming a solution by dissolving indomethacin and a salt of said divalent metal in a tertiary amide or cyclic tertiary amide, adding a C1-4 alkanol or C3-6 ketone to the solution to precipitate the indomethacin metal salt and separating the indomethacin metal salt precipitate from the solution. The present invention still further provides a pharmaceutical composition for alleviating inflammation and pain comprising an anti-inflammatory and analgesically effective amount of salts of indomethacin produced by the process of the invention together with a pharmaceutically acceptable carrier, diluent and/or excipient. |
申请公布号 |
WO9014337(A1) |
申请公布日期 |
1990.11.29 |
申请号 |
WO1990AU00209 |
申请日期 |
1990.05.21 |
申请人 |
BIOCHEMICAL VETERINARY RESEARCH |
发明人 |
REGTOP, HUBERTUS, LEONARDUS;BIFFIN, JOHN, RAYMOND |
分类号 |
C07D209/28 |
主分类号 |
C07D209/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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