LEUKOTRIENE B4 DERIVATIVES, PROCESS FOR PRODUCING THEM AND THEIR USE AS DRUGS

摘要

Compounds of formula (I) in which the residues have the following meanings: a is (II) or (III); R<1> is CH2OH, CH3, CF3, COOR<5> with R<5> or, A is a trans, trans-CH=CH-CH=CH- or tetramethylene group; B is an alkylene group with up to 10 C atoms; D is a direct bond, oxygen, sulphur, a -C=C- group or a -CH=CR<7>-group, or (IV); B and D together are a direct bond; R<2> and R<3> are the same or different and denote hydrogen or an organic acid residue with 1 to 15 C atoms; R<1> and R<2> together are a carbonyl group; R<4> is a hydrogen atom or C1-10 alkyl, and, if R<5> denotes a hydrogen atom, their salts with physiologically acceptable bases and their cyclodextrin clathrates.