| 摘要 |
A method for the preparation of (cis-1,2-epoxypropyl)-phosphonic acid and its salts and ester derivatives which comprises treating a propionaldehyde substituted in the 2-position by a leaving group with: (1) an alkali metal dihydrocarbylphosphite, (2) a trihydrocarbylphosphite or (3) a di-alkali metal phosphite. Suitable leaving groups include halogen, alkarylsufonyloxy, alkanesulfonyloxy or a sulfonium, sulfoxonium, ammonium or phosphonium cation. The (cis-1,2-epoxypropyl)phosphonic acid product thus obtained and its salts are antibiotics which have utility as antibacterials in inhibiting the growth of gram-negative and gram-positive pathogenic bacteria.
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