| 摘要 |
The subject invention discloses methods of inhibiting growth of tumor cells which comprise contacting the cells with a growth inhibiting amount of a compound having one of structures: (I), wherein R<1> is a hydroxyl or acetyl group; R<2> is hydrogen, -CH2-CH=C(CH3)2 or a methoxy group; R<3> is a hydroxyl, methoxy or acetyl group; R<4> is hydrogen, -CH2-CH=C(CH3)2 or a methoxy group; R<5> is a hydroxyl, methoxy or acetyl group; R<6> is hydrogen or a hydroxyl, methoxy or acetyl group; and R<10> is a methyl group; (II), wherein R<5> is hydrogen or -CH2-CH=C(CH3)2; R<6> is a hydroxyl group; R<10> is hydrogen or a hydroxyl group; R<11> is a hydroxyl or methoxy group; and R<12> is hydrogen or a methyl group (III, IV). This invention also provides compositions for inhibiting growth of tumor cells which comprise one of the above-identified compounds and wherein the compound substituents comprise hydrophilic substituents to increase solubility. |
