ATRIAL PEPTIDE DERIVATIVES

摘要

The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R<1> is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R<2> is a sulfur-containing group; R<3> is a hydrophobic amino acid or dipeptide; R<4> is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R<5> is a hydrophobic amino acid; R<6> is a peptide of up to three amino acids; R<7> is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe< psi >Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R<8> is a sulfur-containing group.