BENZOPYRAN DERIVATIVES

摘要

A compound of formula (I) or, where appropriate, a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein: X represents O or S; Y represents N or N+-O- or a moiety CR¿7? wherein R7 is as defined below; Z represents O, CH2, NR, S(O)n or Z represents a bond; R represents hydrogen, alkyl or alkylcarbonyl, R1 and R2 independently represent hydrogen or alkyl; or R1 and R2 together represent a C2-7 polymethylene chain; R3 represents hydrogen, hydroxy, alkoxy or acyloxy; R4 is hydrogen; R5 is hydrogen or R4 and R5 together represent a bond; R6 represents hydrogen, substituted or unsubstituted alkyl, alkoxy, C3-8 cycloalkyl, hydroxy, nitro, cyano, halo, formyl, carboxy, a group of formula R?aT1-, RbRcNT-, RaT2NH-, Rd¿CO.O-, RdCS.O-, Rd(OH)CH-, Rd(SH)CH-, RdC(=N.OH)-, RdC(=N.NH¿2?)- or alkenyl optionally substituted by alkylcarbonyl, nitro or cyano; when Y represents CR7, R7 is independently selected from the variables mentioned above in relation to R6 providing that at least one of R6 or R7 is other than hydrogen; R?a¿ represents Rd or RdO- and Rd represents substituted or unsubstituted alkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl, optional substituents for Rd being up to 3 substituents selected from alkyl, alkoxy, hydroxy, halo, haloalkyl, nitro and cyano; R?b and Rc¿ each independently represent hydrogen, alkyl or alkylcarbonyl; T represents a bond or T1, T1 represents -CS- or T?2 and T2¿ represents -CO-, -SO- or -SO¿2?- and R8 represents hydrogen, alkyl or substituted or unsubstituted aryl; R9 represents hydrogen or alkyl, substituted or unsubstituted aryl or R8 and R9 together represent a C3-7 polymethylene group; and n represents 0, 1 or 2; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound or composition in medicine.