发明名称 |
NEUTROPHIL-ACTIVATING PEPTIDE-2 |
摘要 |
Peptides having the amino acid sequence <IMAGE> AGE> <IMAGE> wherein X is H, Asp-Leu-Tyr-, Ser-Asp-Leu-Tyr- or Asp-Ser-Asp-Leu-Tyr-. The peptide wherein X is H is human neutrophil-activating peptide-2 (hNAP-2) and those wherein X is other than H are natural variants thereof. The peptides have neutrophil-stimulating activity, are structurally related to NAF/NAP-1, beta -thromboglobulin, PBP and CTAP-III and may be isolated from leukocytes and platelets and synthesized by standard peptide synthesis processes and recombinant DNA techniques. |
申请公布号 |
GB2231872(A) |
申请公布日期 |
1990.11.28 |
申请号 |
GB19900011468 |
申请日期 |
1990.05.11 |
申请人 |
* SANDOZ AG;* THEODOR KOCHER INSTITUT |
发明人 |
MARCO * BAGGIOLINI;KENNETH JOHN * CLEMETSON;ALFRED * WALZ |
分类号 |
C12N15/09;A61K38/00;A61P7/02;A61P17/00;A61P29/00;A61P37/00;A61P37/04;C07K1/20;C07K1/22;C07K14/435;C07K14/52;C07K14/54;C07K16/00;C12N15/12;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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