发明名称 |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13. |
摘要 |
<p>The Indian Ocean sea hare Dolabella auricularia has been found to contain a new cell growth inhibitory and antineoplastic (P388 leukemia) cyclodepsipeptide designated dolastatin 13 and a companion substance dehydrodolastatin 13. A series of high field (400 MHz) 2D-NMR experiments including sequential analyses by HMBC and NOE techniques and tandem mass spectrometry provided structural determinations. Dolastatin 13 and dehydrodolastatin 13 represent a new class of cyclodepsipeptides. Pharmaceutical preparations and therapeutic regimens employing these new cytostatic depsipeptides are disclosed. The depsipeptides have the following structure: <CHEM> o</p> |
申请公布号 |
EP0399685(A1) |
申请公布日期 |
1990.11.28 |
申请号 |
EP19900304859 |
申请日期 |
1990.05.04 |
申请人 |
ARIZONA BOARD OF REGENTS |
发明人 |
PETTIT, GEORGES R.;KAMANO, YOSHIAKI DR |
分类号 |
A61K38/00;A61P35/00;A61P35/02;C07K5/10;C07K7/06;C07K11/00;C07K11/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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