发明名称 |
PROCESS FOR PRODUCING NEW R(-)-3-QUINUCLIDINOLE DERIVATIVES |
摘要 |
Pharmacologically active R(-) 3-quinuclidinol derivatives are described which are muscarinic receptor blocking agents useful for the treatment of gastrointestinal and respiratory tract disorders of the following formula (I) <CHEM> wherein R represents a linear or branched lower alkyl group, a cycloalkyl-C1-2alkyl or an aralkyl group, or it is absent; X represents the anion of an organic or inorganic acid, or it is absent, when R is absent; R1 represents H, a linear or branched lower alkyl group or an acyl group of the type R2-CO, in which R2 is H or a linear or branched lower alkyl group; A represents a cycloalkyl, an aromatic ring or a 5- or 6-membered heterocyclic ring; Y and Z may be simultaneously or alternatively present or absent; when they are simultaneously present, they represent oxygen; when only one of them is present, it is oxygen or sulphur; n is 1, 2 or 3; A and the 3-quinuclidinyl ester groups are inserted simultaneously on the same carbon atom of the ring to give rise to a geminal substitution. The process of the preparation of the compounds of formula (I) as well as pharmaceutical compositions containing them are also described. |
申请公布号 |
HU903908(D0) |
申请公布日期 |
1990.11.28 |
申请号 |
HU19900003908 |
申请日期 |
1990.06.19 |
申请人 |
INSTITUTO DE ANGELI S.P.A.,IT |
发明人 |
CEREDA,ENZO,IT;BIETTI,GIUSEPPE,IT;SCHIAVI,GIOVANNI BATTISTA,IT;DONETTI,ARTURO,IT;SCHIAVONE,ANTONIO,IT;DOODS,HENRI,DE |
分类号 |
C07D401/12;A61K31/435;A61K31/439;A61K31/445;A61K31/55;A61P1/00;A61P1/04;A61P11/00;A61P11/08;A61P13/02;A61P15/00;A61P25/02;C07D401/14;C07D403/14;C07D409/14;C07D453/00;C07D453/02 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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