发明名称 |
DERIVATIVE OF TISSUE-TYPE PLASMINOGEN ACTIVATOR |
摘要 |
PCT No. PCT/EP90/00194 Sec. 371 Date Sep. 28, 1990 Sec. 102(e) Date Sep. 28, 1990 PCT Filed Feb. 6, 1990 PCT Pub. No. WO90/09437 PCT Pub. Date Aug. 23, 1990.A new thrombolytically active protein is not glycosylated and consists of the following amino acid sequence: 1SYQGNSDCYFGNGSAYRGTHSLTESGASCL PWNSMILIGKVYTAQNPSAQ 51ALGLGKHNYCRNPDGDAKPWCHVLKNRRLT WEYCDVPSCSTCGLRQYSQP 101QFRIKGGLFADIASHPWQAAIFAKHRRSPG ERFLCGGILISSCWILSAAH 151CFQERFPPHHLTVILGRTYRVVPGEEEQKF EVEKYIVHKEFDDDTYDNDI 201ALLQLKSDSSRCAQESSVVRTVCLPPADLQ LPDWTECELSGYGKHEALSP 251FYSERLKEAHVRLYPSSRCTSQHLLNRTVT DNMLCAGDTRSGGPQANLHD 301ACQGDSGGPLVCLNDGRMTLVGIISWGLGC GQKDVPGVYTKVTNYLDWIR 351DNMRP or said amino acid sequence with an additional N-terminal methionine. DNA sequences encoding the thrombolytically active, non-glycosylated protein and pharmaceutical compositions containing said protein are also disclosed. The protein possesses particularly favorable properties when used to dissolve blood clots. |
申请公布号 |
ZA9000861(B) |
申请公布日期 |
1990.11.28 |
申请号 |
ZA19900000861 |
申请日期 |
1990.02.06 |
申请人 |
BOEHRINGER MANNHEIM GMBH. |
发明人 |
DR. ANNE STERN;DR. ULRICH KOHNERT;DR. RAINER RUDOLPH;DR. STEPHAN FISHER;DR. ULRICH MARTIN |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61K38/48;A61K38/49;A61P7/02;C07K1/113;C07K14/745;C12N9/64;C12N9/72;C12N9/88;C12N15/58 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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