发明名称 |
PROCESS FOR PRODUCING MURAMYL-DIPEPTIDE DERIVATIVES AND PHARMACEUTICAL PREPARATIVES CONTAINING THESE COMPOUNDS |
摘要 |
The 3-O-[N-acetylmuramyl-D-isoglutaminyl]-1,2-di-O-palmitoyl-sn-glycerol derivative of formula I <CHEM> wherein the carbon atom marked with an asterisk * has the R or, respectively, the S configuration, possesses interesting pharmacological, in particular immunomodulating properties. It is particularly indicated for use as an immunomodulant, as an adjuvant in vaccines and as a suppressing agent for IgE formation in e.g. type I allergies and atopical dermatitises. It is obtained by deprotection of a corresponding compound having one or more hydroxy groups(s) in protected form. |
申请公布号 |
HU903880(D0) |
申请公布日期 |
1990.11.28 |
申请号 |
HU19900003880 |
申请日期 |
1990.06.15 |
申请人 |
SANDOZ AG.,CH |
发明人 |
CHEDID,LOUIS,FR;DUKOR,PETER,AT;LEFRANCIER,PIERRE,FR;STUETZ,PETER,AT |
分类号 |
A61K38/00;A61K39/39;A61P37/00;A61P37/04;A61P37/08;C07K1/06;C07K9/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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