Synthetic peptides derived from the alpha-subunit of human lycoprotein hormones

摘要

Synthetic peptides corresponding to alpha -subunit of human glycoprotein hormone amino acid regions alpha 31-45, alpha 21-35, alpha 26-46 and alpha 81-92; were found to inhibit binding of 125I-bTSH to human thyroid. Peptides corresponding to regions alpha 26-46 and alpha 31-45 were also found to potently inhibit the stimulation of adenylate cyclase activity by bTSH in a TSH bioassay using FRTL-5 cells and block the action of thyroid stimulating immunoglobulin.