摘要 |
<p>NEW MATERIAL:A polypeptide derivative (salt) shown by the formula [(A) is His, Asn or Gly; (B) is Arg or Gln; (C) is Asp-Val-Gly-Ala or Asn-Thr-Gly-Ser; m and n are 0 or 1; when (A) is His or Asn, at least one of m and n is 0]. USE:A remedy for hyperkalemia, analgesic or antiulcer agent. PREPARATION:For example, an amino-protecting group C end amino acid is bonded to an insoluble carrier such as chloromethyl resin by solid-phase synthesis method, the amino-protecting group is removed, then amino acids are successively bonded according to amino acid sequence of polypeptide and alpha-aminosuberic acid is introduced to the 6th from N end to synthesize a polypeptide chain. Then the polypeptide chain is eliminated from the insoluble carrier and a ring is formed by intramolecular acid amide bond formation reaction to give a polypeptide shown by the formula.</p> |