发明名称 |
Vasorelaxant substance obtainable from human atrium. |
摘要 |
<p>A vasorelaxant substance obtainable in the beta -component (being fractions 42-45 as shown in Figure 3) resulting from:- extracting human atrium cordis by boiling in acetic acid and homogenising; cooling, homogenising and centrifuging the extract to obtain a supernatant; precipitating impurities from the supernatant, evaporating to dryness and redissolving the residue in acetic acid; defatting, desalting and concentrating the solution; eluting with 1N acetic acid, 2N pyridine solution, and 2N pyridine/acetic acid solution (pH = 5), and selecting the fraction eluted by the 2N pyridine/acetic acid solution; lyophilising said fraction and redissolving the lyophilisate in acetic acid, and gel-filtering the dissolved fraction to provide the fractions as shown in Fig 3.</p> |
申请公布号 |
EP0398451(A1) |
申请公布日期 |
1990.11.22 |
申请号 |
EP19900201387 |
申请日期 |
1984.12.20 |
申请人 |
SUNTORY LIMITED;MATSUO, HISAYUKI |
发明人 |
MATSUO, HISAYUKI;KANGAWA, KENJI |
分类号 |
A61K38/00;A61K35/34;A61P7/10;C07K14/00;C07K14/58 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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