摘要 |
<p>Pyrazine derivatives represented by general formula (I), wherein X represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a cyano group, R1 represents a hydrogen atom, a lower alkyl group or a group of (a) (wherein X is as defined above), R2 represents a hydrogen atom, a halogen atom or (a) (wherein X is as defined above), R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a cyano group, a naphthylmethyl group, a benzyl group or (b) (wherein R4 represents a hydrogen atom, a halogen atom or a lower alkylamino group), a carboxyl group or a lower alkoxycarbonyl group or, when taken together, R2 and R3 represent a cyclohexane ring or a benzene ring together with the carbon atoms to which they are bound, provided that the case where X represents a hydrogen atom, R1 represents (a) (wherein X represents a hydrogen atom), and R2 and R3 represent hydrogen atoms and the case where X represents a hydrogen atom, R1 represents a hydrogen atom, R2 represents (a) (wherein X represents a hydrogen atom), and R3 represents a methyl group are excluded. The pyrazine derivatives have a strong blood platelet agglutination depressing effect and a cyclooxygenase inhibiting effect. The above-described compounds are used as blood platelet agglutination inhibitor or anti-inflammatory agents.</p> |
申请人 |
TERUMO KABUSHIKI KAISHA |
发明人 |
SUWABE, YASUSHI TERUMO KABUSHIKI KAISHA;USHIJIMA, HIDETO TERUMO KABUSHIKI KAISHA;HIJIKURO, KOHSHI TERUMO KABUSHIKI KAISHA;SAKURAGI, SHIHO TERUMO KABUSHIKI KAISHA;SUZUKI, TADAHIKO TERUMO KABUSHIKI KAISHA;AKITA, YASUO;OHTA, AKIHIRO |