摘要 |
Polypeptide derivatives of aminophenylpyridazinones of formula: <IMAGE> in which: - R1 is a hydrogen atom or a lower alkyl, advantageously a methyl radical, - R2 is a hydrogen atom; a linear or branched or cyclic alkyl chain of 1 to 10 carbon atoms; a lower aralalkyl optionally substituted by a lower alkyl, a halogen, a hydroxy, a methoxy, a methylthio, a nitro; a heteroaryl(lower alkyl); a guanidino(lower alkyl); an aminocarbonyl(lower alkyl); a hydroxy(lower alkyl); a methylthio(lower alkyl), - R3 is a hydrogen atom or a lower alkyl or R2 + R3 are -CH2-(CH2)n-CH2-, n being an integer from 1 to 4, that is to say that they form a ring with the nitrogen atom, - A represents a cycloalkylamine, a bicycloalkylamine or a arylcycloalkylamine, alkylamine is understood to mean an amine substituted by a lower alkyl radical; - B represents a group <IMAGE> R4 being a hydrogen atom, a lower alkyl or an amino(lower alkyl), X being a group -CH2-SH, -CH2-S-COCH3 or <IMAGE>, R5 being hydrogen or a lower alkyl, an amino(lower alkyl) or an aryl(lower alkyl) and R6 hydrogen or a lower alkyl, as well as their addition salts with pharmaceutically acceptable acids.
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