| 摘要 |
<p>The present invention provides a method for the genetic analysis of a nuclei acid sample comprising: (a) forming homoduplexes and heteroduplexes from at least one polymorphic region in said nucleic acid sample wherein the copy number of all of the variants of said polymorphic region in said nucleic acid sample has been amplified, and (b) differentiating said homoduplexes and said heteroduplexes by means of a nondenaturing gel. The method is very reliable and easy to perform, and can be utilized to analyze any type of polymorphism. The use of a labelled probe is not essential in order to differentiate the homoduplexes and heteroduplexes. Also, if the nucleic acid sample is contaminated with nucleic acid material from other individuals, the method permits such contamination to be readily apparent. Such method can be utilized to, inter alia, diagnose genetic disorders, establish identity and establish parentage.</p> |
