发明名称 |
STABLE LIQUID FORM OF 5-AMINOSALICYLIC ACID |
摘要 |
An aqueous solution of 5-aminosalicylic acid (5-ASA) and a nontoxic alkali, alkali metal or alkaline earth metal salt of 5-aminosalicylic acid having a pH of 3-5 is disclosed. The sole buffer in the solution is that intrinsically formed by 5-aminosalicylic acid and its alkali, alkali metal or alkaline earth metal salt. The solutions preferably also contain an antioxidant and a metal complexing agent. In preferred practice, the 5-ASA salt is formed in situ by addition of an alkali, alkali metal or alkaline earth metal hydroxide to a solution of 5-ASA. The solution is stable and does not significantly discolor due to 5-ASA decomposition for extended periods of time. MO1529
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申请公布号 |
CA2016825(A1) |
申请公布日期 |
1990.11.15 |
申请号 |
CA19902016825 |
申请日期 |
1990.05.15 |
申请人 |
MARION MERRELL DOW INC. |
发明人 |
BOTTOM, CAREY B.;KWOKA, MARGARET N. |
分类号 |
A61K9/00;A61K31/60;A61K47/02;A61K47/18;A61K47/22;C07C227/44;C07C229/64;C09K15/06;C09K15/12;(IPC1-7):A61K31/195 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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