This invention pertains to soluble peptides and DNA encoding the peptides that correspond to the cytoplasmic domain of human CD2 glycoprotein or portion thereof which is necessary for transduction of a CD2-mediated T lymphocyte activation signal into a cell. The invention also pertains to cells transformed to express a CD2 surface receptor, and to methods for screening substances which stimulate or block CD2 receptor function.
申请公布号
WO9013644(A2)
申请公布日期
1990.11.15
申请号
WO1990US02584
申请日期
1990.05.09
申请人
DANA FARBER CANCER INSTITUTE
发明人
REINHERZ, ELLIS, L.;CHANG, HSIU-CHING;MOINGEON, PHILIPPE