| 摘要 |
<p>The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, or therapeutically-conjugated, chemotactic peptide which accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure N - X - Y - Leu - Phe - Z - W; where: X = Formyl for agonists - a more bulky group such as t - Boc for antagonist; Y = Met or Nle; Z* is a spacer sequence such as Gly - Gly - Gly; W* is a labeling or attachment substituent, i.e., N-epsilon (DTPA) Lys - putrsine for labeling; OSU (SO¿3?) for attachment to a high molecular weight carrier; *At the Z and W positions either D or L amino acids can be used.</p> |
