2-Phenylthiobenzylamine dervivatives and acid addition salts thereof.

摘要

N,N-Dimethyl-2-(3-hydroxyphenylthio)benzylamine and its acid addition salts possess properties of highly selective inhibitors of 5-hydroxytryptamine re-uptake in mammalian brain structures and are expected to find therapeutic use as potent central antidepressants. This novel compound and its intermediate, the 3-methoxyphenylthio analog, are available by per se known preparative routes, especially by reduction of the corresponding amides with hydride agents, by Leuckart reaction of 2-arylthiobenzaldehydes with dimethylformamide and formic acid, or by demethylation of the respective methoxy compound by means of e.g. pyridine hydrochloride or hydrobromic acid.