发明名称 |
Process for producing beta-lactamase inhibitor. |
摘要 |
<p>A process for producing the compound [2S-(2 alpha ,3 beta ,5 alpha )]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-aza bicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol in toluene at 80-100 DEG C for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0-10 DEG C.</p> |
申请公布号 |
EP0396901(A1) |
申请公布日期 |
1990.11.14 |
申请号 |
EP19900106310 |
申请日期 |
1990.04.02 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
KRISHNAN, RAGHAVAN;GAMBLE, JESSE;BLUM, DAVID;CURRAN, WILLIAM V.;LEE, VING J.;CONROW, RANSON B. |
分类号 |
C07D499/87;A61K31/43;A61P31/04;C07D499/00;C07D499/86;C07D499/897 |
主分类号 |
C07D499/87 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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