| 摘要 |
TITLE OF THE INVENTION ENANTIOSELECTIVE PROCESS FOR PRODUCING 1-BETA-METHYLCARBAPENEM ANTIBIOTIC INTERMEDIATES A process is described for the stereocontrolled synthesis of intermediates useful in producing 1-betamethylcarbapenem antibiotics. An example of a compound prepared by the process of the present invention, would be a compound of Formula II: (II) wherein X1 and X2 are independently O or S, R1 is C1-C4 lower alkyl or alkoxyl, R2 and R9 are independently selected from hydrogen, C1-C4 linear, branched or cyclic alkyl, unsubstituted or substituted with fluoro, hydroxy, or protected hydroxy, with the proviso that both R2 and R9 are not unsubstituted alkyl, R3 is H or easily removable protecting group, R4, R5 and R6 are independently selected from H, C1-C4 alkyl, C7-C10 aralkyl, C6-C10 aryl, C7-C10 alkaryl, which can be substituted with -OH, -OR10, -SH, -SR10, where R10 is C1-C4 alkyl, with the proviso that R4 and R5 are not identical. |
