HYBRID STREPTOKINASES WITH FIBRIN BINDING DOMAINS AND METHODS FOR SYNTHESIS OF SAME

摘要

Compositions and methods for the synthesis of hybrid streptokinase with fibrin binding domains based on gene fusion technology. Recombinant DNA methods have been used to fuse gene segments for streptokinase and for fibrin-binding domains and express the fused gene in prokaryotic microorganisms, and the respective expressed protein is subsequently obtained by biotechnologic fermentation for the purpose of use in clinical medicine.