MONOCLONAL ANTIBODIES (MABS) AGAINST TUMOR-ASSOCIATED ANTIGENS, THE PREPARATION AND USE THEREOF

摘要

The invention relates to murine monoclonal antibodies (MAbs) A, B, C and D which are directed against tumour-associated antigens. The almost complete nucleotide sequences of the V genes of these MAbs are described so that the relevant variable domains can be assembled to chimeric MAbs, or "humanised" MAbs are obtained by inserting the hypervariable regions (Complementarity Determining Regions = CDR) into a human MAb framework. Such antibody constructs can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.