发明名称 |
Synthesis of thalicarpine |
摘要 |
There is disclosed a novel total synthesis of thalicarpine which includes inter alia a total synthesis of hernandaline. The novel process is characterised in utilizing simple and readily available starting materials to form a diaryl ether system which is then condensed with a 3,4-dihydroisoquinolinium salt which is then converted to hernandaline. Hernandaline is reacted with a bicyclic Reissert compound to yield a compound having the thalicarpine skeleton, nascent hydrogen reduction yields N-monodesmethyl thalicarpine which is methylated.
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申请公布号 |
US3875167(A) |
申请公布日期 |
1975.04.01 |
申请号 |
US19720257215 |
申请日期 |
1972.05.26 |
申请人 |
RESEARCH CORPORATION |
发明人 |
KUPCHAN, S. MORRIS;LIEPA, ANDRIS J. |
分类号 |
C07C205/37;C07C205/38;C07D217/20;(IPC1-7):C07D43/28 |
主分类号 |
C07C205/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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