Novel pyrimidinone derivatives.

摘要

A compound of formula (I) : <CHEM> wherein R<1> and R<2> are independently selected from hydrogen, halogen, haloalkyl, alkoxy or nitro, provided that R<1> and R<2> are not both nitro; R<3> and R<4> are independently selected from hydrogen, halogen, alkyl or cycloalkyl; R<5> is halogen, nitro, haloalkyl, haloalkoxy or -S(O)nR<1><0>; R<6> is halogen, nitro, haloalkyl, haloalkoxy or -S(O)nR<1><0>; R<7> is hydrogen, halogen, hydroxyalkyl, cyano, nitro, alkoxy, -S(O)nR<1><0>, NR<1><1>R<1><2>, haloalkyl or formyl; R<8> is hydrogen, halogen, NR<1><1>R<1><2>, alkyl, cycloalkyl or S(O)n R<1><0>; and R<9> is oxygen or sulphur; where n is 0, 1 or 2; and R<1><0> is alkyl, haloalkyl or cycloalkyl; and R<1><1> and R<1><2> are independently selected from hydrogen, alkyl or cycloalkyl or R<1><1> and R<1><2> together with the nitrogen to which they are attached form a heterocylic group; provided that when R<5> is trifluoromethyl at least one of the following applies: (i) R<1> or R<2> is haloalkyl or alkoxy; (ii) R<3> or R<4> are alkyl or cycloalkyl; (iii) R<6> is haloalkoxy, nitro or -S(O)nR<1><0>; (iv) R<7> is nitro, hydroxyalkyl, alkoxy, S(O)nR<1><0>, NR<1><1>R<1><2>, formyl or haloalkyl; (v) R<8> is other than hydrogen; (vi) R<9> is sulphur; and further provided that (a) R<1>, R<2>, R<3> and R<4> are not all fluorine and (b) when R<5> is chlorine, R<1> and R<2> are both halogen.