Phosphates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These phosphates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the phosphates are also disclosed.
申请公布号
US4968790(A)
申请公布日期
1990.11.06
申请号
US19880264480
申请日期
1988.10.28
申请人
AMERICAN CYANAMID COMPANY
发明人
DEVRIES, VERN G.;CLAUS, THOMAS H.;FLOYD, JR., MIDDLETON B.;AYRAL-KALOUSTIAN, SEMIRAMIS
