发明名称 |
Use of purified hematoporphyrin trimers in photodynamic therapy |
摘要 |
Pure dimer and trimer compounds of hematoporphyrin are prepared and shown to be effective agents in photodynamic therapy. The compounds of the invention are of the formula <IMAGE> (1) or <IMAGE> (11) <IMAGE> <IMAGE> (2-A) <IMAGE>OMe HCNHMe NMeMeHO MeHNCO2R NMeCO2R+RE wherein each X is independently 1-hydroxyethyl or vinyl and wherein R is H or lower alkyl. The compounds of the invention can be conjugated to targeting substances such as immunoglobulins or to labels.
|
申请公布号 |
US4968715(A) |
申请公布日期 |
1990.11.06 |
申请号 |
US19890343865 |
申请日期 |
1989.04.26 |
申请人 |
HEALTH RESEARCH, INC. |
发明人 |
DOUGHERTY, THOMAS J.;PANDEY, RAVINDRA K. |
分类号 |
C07D487/22;A61K31/40;A61K39/44;A61K41/00;A61P35/00;C07D519/00 |
主分类号 |
C07D487/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|