CEPHALOSPORIN DERIVATIVES

摘要

The invention relates to a cephalosporin derivative of the formula: <IMG> wherein Y is straight or branched C1-C5 alkyl or alkenyl chain, C3-C6 cycloalkanomethyl , each group being optionally substituted by halogen, or a group <IMG> wherein n is 0 or an integer of 1 - 3, A is a group -COR3 wherein R3 is hydroxy, a group <IMG> wherein R4 and R5, which may be the same or different, are hydrogen or C1-C5 alkyl, a group <IMG> or a 5- or 6membered heterocyclic group containing nitrogen and/or sulfur, and R1 and R2, which may be the same or different, are hydrogen, C1-C5 alkyl, or R1 and R2 may be combined together to form a C1-C5 cycloalkylidene and Z is a group of the formula: <IMG> wherein m is an integer of 3 - 5, R6 is hydrogen or alkyl of 1 - 3 carbon atoms, and R7 is alkyl or alkenyl of 1 - 5 carbon atoms, cyclopropyl, a group -(CH2)pB wherein p is 0 or an integer of 1 - 3 and B is amino, alkyl-substituted amino, hydroxy, carboxy, carbamoyl, trifluoromethyl, sulfonic acid, sulfonic acid amide, alkylthio or cyano or a pharmacologically acceptable salt thereof. These compounds have a strong antibacterial activity against Gram positive organisms as well as Gram negative organisms.