| 摘要 |
A beta -lactam of the formula <IMAGE> +TR <IMAGE> or a hydrate thereof, in which R represents a hydrogen atom or a methoxy group, n is 1 or 2, Z represents a group of the formula <IMAGE> wherein R1 denotes an optionally substituted aryl group or an optionally substituted heterocyclyl group; or, when n is 1, Z can also represent an optionally substituted cycloalkyl group or an optionally substituted pseudoaromatic heterocyclic 5-membered or 6-membered ring, B represents an optionally substituted phenyl or cyclohexadienyl group, or an unsaturated optionally subtituted heterocyclic ring, T denotes an alkyl-CO-O-, pyridinium, aminopyridinium, carbamoylpyridinium or carbamoyloxy group, an -S-phenyl group which can be substituted, or an -S-Het group in which Het represents an optionally substituted heterocyclic 5-membered or 6-membered ring; and E represents a hydrogen atom, a pharmaceutically acceptable ester grouping a salt-forming cation or a protective group, or represents a negative charge when T contains a quaternary nitrogen, which possesses antibacterial activity rendering it useful as an antibiotic and animal feed supplement. |
