RHODOMYCIN DERIVATIVES WITH CYTOSTATIC ACTIVITY

摘要

The invention relates to anthracycline derivatives which have cytostatic activity and the formula I and to the physiologically acceptable salts thereof, where R<1> is hydrogen or a hydroxyl group, R<2> is Cl, Br, OCOR, NRR, NR-(CH2)n-NRR, NR-NR-CO-(CH2)y-CO-NR-NRR or NR-CHR<3>R<4>, where R is C1-C6-alkyl, phenyl or benzyl, n = 0-12 and y = 0-10, where R and R can each be hydrogen, C1-C4-alkyl or benzyl, and where R<3> is hydrogen or a carboxyl group and R<4> is the residue of an L-amino acid or a biogenic amine, to a process for the preparation thereof and to the use thereof in a pharmaceutical.