| 摘要 |
A solid state, resilient laminated composite for administering estradiol transdermally consisting of a multiplicity of spaced structural laminas (12, 14, 16) of a resilient elastomer, one of which (12) forms the top of the composite, a viscoelastic hydrophobic polymer lamina (13, 15) containing propylene glycol monolaurate interposed between each structural lamina (12, 14, 16) and a pressure-sensitive adhesive lamina (17) that provides the basal surface of the composite and consists of a blend of a pressure-sensitive adhesive, estradiol, and propylene glycol monolaurate. |
